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The aggressive course and poor prognosis of MNTI are based on the following prognostic indicators: nuclear schistosomes seen in more than 2 out of 10 high power fields (HPFs)

(Waller et al., 1987) conserve 80 % de son activit pH 3

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(6) Complex I: Complex I (NADH:ubiquinone oxidoreductase) is a large multiprotein complex located in the mitochondrial inner membrane that accepts electrons from NADH and transfers them to ubiquinone (CoQ 10 ) via FMN and a series of ironsulfur (FeS) clusters, reducing it to ubiquinol (CoQ 10 H 2 ) 68,69